We Just Got More Evidence Our Leading Hypothesis About Alzheimer's Could Be Wrong

We Just Got More Evidence Our Leading Hypothesis About Alzheimer’s Could Be Wrong

by Mike McRae, ScienceAlert

The leading hypothesis on the cause of Alzheimer’s is looking shaky, following a new study that tracked the disease’s early progress in hundreds of volunteers.

For more than 30 years, amyloid plaques have been primary suspects in the cause of dementia. While the potentially toxic accumulations of protein still seem to be related, this research is part of a growing body of evidence that suggest they’re actually latecomers to the disease rather than an early trigger.

Scientists from University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System came to this conclusion after analysing brain scans of individuals showing subtle signs of cognitive decline.

According to the amyloid cascade hypothesis, knotted fragments of a common protein found in cell membranes are responsible for the degeneration behind Alzheimer’s symptoms of memory loss and confusion.

Read the full article here…

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